LA-ICP-MS of Metalloproteins and Tissue
A) Recent LA-ICP-MS applications include the elemental analysis of metalloproteins within a native electrophoresis gel, as seen in Science. B) Thin sections of tissue, such as this tumor sample, are imaged via LA-ICP-MS to produce 2-D elemental maps.
The HPLC is used to separate elemental species such as As(III) and As(V) (shown here), Cr compounds, Pt compounds, etc. These species are then quantified by ICP-MS at ppt-ppb detection limits.
Upright Confocal Meta Detector
The Meta detector allows for multi-wavelength spectral detection to resolve complex mixtures of emission signals.
STEM - Hitachi HD-2300
A) HD-2300 Schematic: Adapted from Figure 3-1 HD2300A Electron Optics
Hitachi High-Technologies Corporation
B) STEM-EDX Mapping
The Hitachi HD-2300 STEM is equipped with dual EDX (x-ray Energy Dispersive Spectroscopy) detectors for enhanced sensitivity.
Zeiss Stage Mounted Incubation: CO2, Heat, and Humidity
The incubator is compatible with Petri dishes (35mm and 60mm) and slides. The CO2/air mixture is humidified and delivered into the incubation chamber. The heating insert is equiped for perfusion tubing if necessary. Temperature range: 3°C above ambient to +60°C.