QBIC is a core within the Integrated Molecular Structure Education and Research Center (IMSERC) at Northwestern focusing on ultra-trace elemental analysis by inductively coupled plasma (ICP). Researchers from multiple distinct research areas and Colleges at Northwestern have come to rely on QBIC for ultrasensitive quantification of trace elements in cells, tissues,
environmental samples, and various synthetic materials. Areas served include materials science, nanoscale materials, mineral samples, chemotherapeutics (cisplatin derivatives as well as Au nanoparticles), imaging probes (Gd- and Fe-
based agents), and clinical medicine (biodistribution and toxicity of clinical specimens), among many others.
Including our external users, we actively serve approximately 200 researchers at any given time.
The core has facilitated these investigations by developing a suite of inductively coupled plasma mass spectrometry instruments (ICP-MS) and optical emission spectroscopy instruments (ICP-OES) that provide highly precise elemental measurements with sub-ppb (parts per billion) levels of accuracy. Equally important, the core provides in-depth training and consultation on sample preparation, including skilled technician assistance with microwave digestion or hydrofluoric acid treatment, where necessary. Highly trained personnel within the facility routinely aim to convert the inexperienced customer into a knowledgeable, and therefore highly effective, scientist.